- Title
- Unchanged cellular inflammatory response following recurrent ST-elevation myocardial infarction
- Creator
- Lim, Joyce; King, James; Williams, Trent; Boyle, Andrew
- Relation
- International Journal of Cardiology Vol. 398, no. 131656
- Publisher Link
- http://dx.doi.org/10.1016/j.ijcard.2023.131656
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2024
- Description
- Background: Recurrent ST-elevation myocardial infarctions (STEMIs) are associated with poorer prognosis. A diminished haematopoietic response has been proposed as the mechanism responsible for this, but has yet to be validated in human studies. We therefore aim to map out the leukocyte response, and its subtypes, following the first and second STEMI to identify if the inflammatory response is dampened after recurrent myocardial infarctions. Methods: Retrospective cohort study of patients presenting with recurrent STEMI undergoing percutaneous coronary intervention. Full blood counts were taken within 24 h of each admission, and daily thereafter. The primary outcome was whether there were any qualitative or quantitative difference in leukocyte cell response (and its subtypes) between first and second STEMI. Results: Thirty-one patients (mean age 59 years [SD 14.9], 26 males [83.9%]) with an average of 3.1 years between infarcts were included in the study. Overall, between first and second STEMI, similar mean leukocyte response (and its subtypes) was observed from admission to day three post PCI. Similarly, the peak leukocyte response (and its subtypes) was similar between the two STEMIs, even after adjusting for infarct size. Conclusions: In recurrent STEMIs, there is no long-term memory effect on the cellular inflammatory response leading to diminished peripherally circulating leucocytes, and its subtypes.
- Subject
- inflammation; recurrent ST-elevation myocardial infarction; leukocytes; retrospective cohort study
- Identifier
- http://hdl.handle.net/1959.13/1499130
- Identifier
- uon:54626
- Identifier
- ISSN:0167-5273
- Language
- eng
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